Endocrine Abstracts

Autoimmune hypothalamitis has been implicated in idiopathic central diabetes insipidus (DI) due to antibodies against vasopressin producing hypothalamic cells. Lymphocytic infiltration of hypothalamus has been reported in patients with lymphocytic hypophysitis (LH) manifesting as hypopituitarism with DI. These patients can also have other associated autoimmune diseases. Here, we report a case of a male patient who presented with headache, poor orientation, partial hypopituitar...

Women affected by Cushing’s disease (CD) are often infertile due to abnormal follicular development or anovulation. In these patients, first line treatment is pituitary surgery, which is effective in more than 83% of cases with microadenomas, but only in about 35% of those with macroadenomas. When surgery do not normalize circulating ACTH and cortisol concentrations, such drugs, e.g. ketoconazole or metirapone, and radiotherapy are used as adjuvant treatment. Concerning r...

Nodular thyroid disease is frequently observed in patients with acromegaly. The aim of this study is to evaluate thyroid nodules and thyroid cancer frequency in acromegalic patients. The data of 125 acromegalic (55 males and 70 females) patients followed over 10 years were evaluated retrospectively from the recorded files. Data for gender, age, duration of acromegaly, thyroid function tests, thyroid ultrasonography (US), and thyroid fine needle aspiration biopsy (FNAB) and thy...

Introduction: Acromegaly is a chronic endocrinopathy characterized by hypersecretion of GH and insulin-like growth factor 1 (IGF1). Musculoskeletal pain is a frequent problem encountered in acromegaly and is associated with a reduction in quality of life. In this study we investigated the presence of inflammatory, rheumatologic and degenerative disease retrospectively.Methods: Fourty acromegaly patients who were in remission as laboratory findings but wh...

The increased morbidity and mortality of acromegaly makes early diagnosis and therapy critical. Long term follow-up and investigating comorbidities of this disease is also important. We present here retrospective results of 70 patients. There were 41 female, 29 male patient included in the study. Follow-up period was longer than 5 years. Fifty-nine of the patients were macroadenoma, 4 of them were empty sella, 7 of them were microadenoma. Seven patients refused surgical treatm...

Acromegaly is usually regarded as a disease which occurs sporadically. Familial occurence of acromegaly due to pituitary adenoma without any other endocrinopathy in a family is extremely rare. These patients should be evaluated for multiple endocrine neoplasia type 1 (MEN 1) and Carney complex. We report here two cases of acromegaly due to pituitary macroadenomas. Subject 1 is a 50-year-old woman and subject 2 is her 23-year-old son with elevated growth hormone (GH) levels dur...

Objective: It is very important to determine the malignancy risk in thyroid nodules for to improve therapeutic strategies. In this study we attempted to evaluate the relationship of doppler (DUS) and B- mode ultrasonographic (BUS) features of thyroid nodules with fine needle aspiration (FNA) findings.Method: 111 patients which have been followed between March and September 2004 were evaluated with ultrasonography and ultrasound guided FNA was performed i...

Congenital morphological thyroid abnormalities can be classified as hemiagenesis or total agenesis, lingual thyroid, substernal thyroid, thyroglossal ductus remnant. Hemiagenesis with absence of one lobe or lobe and isthmus is very rare, it was found in 4 of 7000 scans in one study. The left lobe is absent four times as often as the right lobe, and women are about three times more likely than men to have this developmental defect. Usually diagnosing this condition is not very ...

Various abnormalities of coagulation may occur in patients with thyroid disorders and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation. Tissue factor pathway inhibitor (TFPI) is a newly determined potent inhibitor of tissue factor dependent coagulation system. TFPI changes in various thyroid disorders has not been evaluated yet. In this study we have evaluated total TFPI (tTFPI), free TFPI (fTFPI), tissue plasminogen act...

Non-hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, hypothalamus involvement is a rare presentation. Here, we report a case of hypothalamic infiltration of NHL Diffuse Large B-cell lymphoma (DLBCL) in a 21 years old male patient with panhypopituitarism and diabetes insipidus. The patient was admitted to the hospital with a history of nausea, vomiti...